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Difference Between Plasma And Serum

bloodPlasma and serum are two very common terms you hear on a regular basis. Did you know that there are a number of differences between the two?
Both plasma and serum are important parts of blood. The blood comprises of plasma, serum, white blood cells (cells that fight foreign bodies) and red blood cells (cells that carry oxygen). The main difference between plasma and serum lies in their clotting factors.

A substance called fibrinogen is essential in blood clotting. The blood plasma contains this fibrinogen. Basically, when serum and plasma are separated from the blood, plasma still retains the fibrinogen that helps in clotting while serum is that part of the blood that remains after this fibrinogen is removed.

What remains of the blood once the red blood cells, white blood cells and clotting factors have been removed? Blood serum is mostly water that is dissolved with proteins, hormones, minerals and carbon dioxide. It is a very important source of electrolytes.

When you donate blood, it is separated into a number of parts, so that it can be given to specific patients. Blood is separated into proteins (albumin etc), red blood cells and white blood cells. This helps hospitals in custom treating patients. For instance, if a patient has liver failure, he may be provided blood plasma together with the clotting factors. It is also given to patients who have problems with blood clotting.

Plasma is a clear and yellowish fluid part of the blood. It is also found in lymph or in intramuscular fluids. This is the part of the blood that contains fibrin and other clotting factors. Plasma makes up about 55% of the total blood volume. The main constituent of blood plasma is water.

How do medical professionals split the various components of blood? The process is highly complicated. Blood plasma is prepared by spinning the test tube containing blood in centrifuges till the blood cells are isolated at the end of the tube. Once this has been done, the plasma is drawn off. Blood plasma normally has a density of 1.025kg/l. the wonderful thing about this plasma is that it can be stored for even 10 years from the date it has been collected. Plasma is the cell free part of the blood and it is usually treated with anticoagulants.

Serum is the liquid part of the blood after the coagulation. They contain 6-8% of the proteins that make up blood. They are more or less equally divided between serum albumin and serum globulins. When blood is extracted and left to clot, the clot shrinks after some time. The serum is squeezed out once this clot shrinks. The proteins in the serum are usually separated by a process called electrophoresis.

1. Plasma is the part of the blood that contains both the serum and clotting factors.
2. Serum is the part of the blood that remains once the clotting factors like fibrin have been removed.
3. Plasma contains the clotting factors and water, while serum contains proteins like albumin and globulins.

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  1. so much simple and easy understanding…really very nice notes on difference….

  2. well done for such good information

  3. Very nice and easily difinations that plasma and serum

  4. thank you for this good and simplified explanation

  5. very thankfull to u, bcz to to clear my doubt about serum and plasma ,so deeply its goes to my mind ,after reading thank u

  6. its really nice to know thank you for valuable information

  7. thank you so much.. it very helpful.
    short but full with important information 🙂

  8. It is very nice to know about very closely related terms.

  9. It is very clear about their d/ce but thei separation process ?????????/

  10. Thanks a lot!

  11. Yes! I realy understand ur point of differenciation. Tanx u.

  12. I just resumed work in a medical diagnostic lab 4 my post grauate xperience as a microbiologist and dis answer was helpful

  13. Wow!this has really given me an insight in what I’ve been looking for

  14. Very easy & clear definitions.it’s really Helpful Thanks a lot.

  15. Thanks, simple and clear explanation

  16. very thankfull to u

  17. Thanks alot. It’s easy to understand.

  18. VERY NICE…………!!!!!

  19. Thanks for the simple and easy to understand answer.

  20. Straw-Bery Nice… 🙂

  21. Thanks, your simple explanations helped me to attain clear picture about serum.

  22. Thanx buddy nice information

  23. Thanks this is exactly what i need

  24. thax for the info..

  25. thanks a’lot. Good explanation.

  26. Simple explanation, but oversimplified. Plasma also contains albumin and globulins and many other proteins (how would otherwise the antibodies of our immune defense get transported around?). The difference is that plasma is blood devoid of blood cells. When blood clots, some proteins, the so-called coagulation factors, form the blood clot (and hence, they are removed from serum). There are also proteins added to the serum from the platelets that release their content upon coagulation. In other words, serum is plasma devoid of fibrinogen and other stuff that is involved in coagulation, but it also contains factors that plasma doesn’t contain (such as the growth factors platelet-derived growth factor and transforming growth factor beta that are released from the platelets upon coagulation). Most of the proteins of serum also exist at the same concentration in plasma. By the way, I am a scientist working with these things, and I teach at Medical School.

  27. Thanks to provide very useful information in simple words.

  28. I love how you explained it!
    Very simple and understandable wording.. I was still confused on it until I read about it here.

    Thanks for posting

  29. Thank u so much for ds information . its very easy to understand……..

  30. its really nice to know thank you for valuable information.

  31. Thank u for your information.it is very useful for me and it is clear and shortest ans.

  32. this is awesome…

  33. I like it.well explained & simplified

  34. I am researcher, doing pharmacological studies of traditional medicinal plants, especially liver necrosis caused by alcohol consumption, i have to work on animals and study their blood composition eg., serum levels of biochemical parameters, could any body plz explain me about different levels of biochemical parameters in serum.

  35. Thank you so much for taking the time to write this! Clear and easy to understand. I like the summary at the end, too. My textbook should have it laid out so clearly!

  36. Thanks alot for d insight

  37. A lot of wishes to u for increasing our knowledge for a short time….

  38. well noted!!! thanks very much for the explanation.

  39. Thank very interested explanation.

  40. i was confused about that but now it is clear very well

  41. wonderfully summarised!keep it up!

  42. Helpful. Thank You.
    So serum is mostly water, with some ‘growth factors’ and proteins, if this lay-person grasps all the above…
    How I got here? Was just wondering what the juice was, under a blister. Looked like slightly thicker water, perhaps.


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