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Difference Between 7-Keto DHEA and DHEA

7-Keto DHEA vs DHEA

“DHEA” stands for “dehydroepiandosterone.” It is a hormone synthesized in the human body naturally. 7-Keto DHEA is a metabolite product which is derived from the hormone DHEA. They are similar in structure but have many different functions and properties.


DHEA is a naturally occurring hormone being synthesized by the adrenal glands. Adrenal glands are the endocrine glands located above the kidneys which synthesize hormones related to stress. As this hormone is released from the adrenal glands, it is also called as androstenolone. The chemical name of this is called 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one.

DHEA is metabolized into another product which is called DHEAS or dehydroepiandrosterone sulfate in the liver. This DHEAS later on converts into androgens and estrogens. Androgens are the male hormones comprised of; testosterone, androstenedione and dihydrotestosterone. The female hormones are estradiol and estrone which are grouped under estrogens.

DHEA performs a wide range of effects on the human body. It is said to slow down the process of aging and improve thinking skills in elderly people. It is also helpful in the treatment of Alzheimer’s disease. It is used in increasing  sexuality by increasing the levels of certain hormones. In males, DHEA prevents erectile dysfunction, while in females it decreases the problems related to menopause. Its external administration also helps in the treatment of systemic lupus erythematosus, osteoporosis, Addison’s disease, schizophrenia, multiple sclerosis and slowing down Parkinson’s disease. It is also helpful in diabetes and breast cancer. People also use this for boosting their immune system and losing weight. DHEA is also used by athletes for increasing muscle density. DHEA acts as an anti-aging hormone.

7-Keto DHEA

7-Keto DHEA is a metabolite of DHEA. It is a metabolite of a hormone which can enhance the immune functioning and helps in reducing  body fat. 7-Keto DHEA is formed when DHEA breaks down. It is twice as effective as DHEA.

The major difference between DHEA and 7-Keto DHEA is that DHEA converts to testosterone and estrogen while 7-Keto DHEA does not convert into these two sex-related hormones. An increase in the testosterone level in females may cause the growth of beards and facial hair while an increase in estrogen levels in males may give rise to the growth of breasts.

7-Keto DHEA is relatively non-toxic to the body. It may eliminate or significantly reduce the possible side effects of plain DHEA. The side effects of DHEA mainly include hormonal imbalances. Studies show that in certain cases, DHEA might contribute to liver damage or even liver cancer. One of the milder side effects of DHEA is mild acneiform dermatitis.


  1. DHEA is secreted in the body while 7-Keto DHEA is a metabolite of DHEA.
  2. 7-Keto DHEA is twice as efficient as DHEA.
  3. DHEA converts to androgens and estrogens while 7-Keto DHEA does not converts to sex hormones.
  4. DHEA presents a few side effects while 7-Keto DHEA is relatively non-toxic.

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  1. Very helpful clarification!
    I have back trouble post desk lower lumbar excission-bone on bone no padding since 1975! People do generslly notvteslyze the adrenals deliver the flight fright response, but also work hard to stabilize continually correcting the pelvic angle! In short I have really pushed mine! So with a DHEA 100mg regular form and a firm of dehydrated bovine adrenal supplement I can function lifting doing ar age 71! No back surgery could really help! I will with this info try the 7-KETO version! Thx very much!

    • Nancy I have the same situation with my back as you described. Did 7-keto work? What is the brand of bovine complex you used.

  2. “7-Keto DHEA is twice as efficient as DHEA.”

    Efficient in what way? How was this verified? Does 7-Keto DHEA convert into twice as much testosterone as DHEA would per X-mg dosage?

    Testosterone can still be converted into estradiol and other estrogens via the aromatase enzyme.

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