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Difference Between Zoloft and Wellbutrin

Zoloft vs Wellbutrin

Sadness is inevitable in our lives as humans. We may experience sunshine once in a while, but we may also experience rainfalls at the end of the day. We may thank God for these roller coaster rides in our lives since these problems make us better human beings.

When depression hits you and stays for days, weeks, and months, it’s time to consult a physician to give you appropriate medications. Same goes with anxiety as stresses around our environment are also inevitable. Most likely, doctors for emotional disturbances, called psychiatrists, would prescribe you medications such as antidepressants like Zoloft and Wellbutrin. Let us get to know these medications.

The generic name of Zoloft is Sertraline while the generic name of Wellbutrin is Bupropion. Zoloft was manufactured earlier during the 1970’s. Pfizer manufactured it under its chemist, Reinhard Sarges. The inventor of Wellbutrin, on the other hand, was Nariman Mehta of GlaxoSmithKline during 1969. It was marketed as Wellbutrin in the U.S. during 1985. Zoloft is classified under SSRI, or selective serotonin reuptake inhibitor, while Wellbutrin is classified under non-TCA or nontricyclic antidepressants. SSRIs work by the production of serotonin or also known as a “happy hormone.”

The main indication of Zoloft is for major depression and anxiety disorders such as GAD or generalized anxiety disorder up to panic attacks. Wellbutrin, on the other hand, is also indicated for depression disorders at the same time used as a smoking-cessation drug. This is very commendable.

Zoloft and Wellbutrin cannot be given with other drugs such as MAOIs, chemo drugs, painkillers, and anticoagulants as this may exacerbate the condition of the patient. Patients should also be informed that these drugs will not work until after three to four weeks. So they should be patient in taking these drugs.

These drugs should be taken with a full glass of water. They should not be stopped immediately as this may cause withdrawal symptoms to the patient. Thus, there should be a gradual weaning process when using these medications. If adverse reactions occur, call your doctor or go to the nearest hospital.


1. The generic name of Zoloft is Sertraline while the generic name of Wellbutrin is Bupropion.
2. Wellbutrin was discovered earlier than Zoloft.
3. Zoloft is an SSRI while Wellbutrin is a non-TCA drug.
4. Both drugs are for depression and anxiety but Wellbutrin can be used for smoking-cessation.

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1 Comment

  1. You say “SSRIs work by the production of serotonin”, but you do not say how Wellbutrin works.
    Bupropion inhibits the excessive production of dopamine, serotonin, and norepinephrine.
    How can they work together if one work by the production of serotonin and the other inhibits it?

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