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Difference Between Paxil and Zoloft

Paxil vs. Zoloft

A lot of people these days are turning on to medicines for personal support. While this kind of approach is expensive and deemed dangerous when overdosed, it is undeniable that most of the medicines prescribed by the doctors and available over the counter really help lives get better. One of the most common and widely used medicines are Paxil and Zoloft.

Paxil and Zoloft are antidepressants. These medications fall under the selective serotonine reuptake inhibitor type or SSRI. However, they have different features and can treat different symptoms of depressions. Here are the differences of the features of the most highly competing anti-depressants drugs in the market.

Paroxetine or otherwise known as Paxil can treat not only depression, but also disorders such as obsessive compulsive disorder, social anxiety disorder and panic disorder. GlaxoSmithKline is the company that manufactured the drug Paxil. It went out public in the early 90’s and entered the market earlier than Zoloft. While this drug help cease depression among patients, it also carries side effects that vary from normal to extensive. Normal side effects of Paxil include dryness of mouth, loss of appetite, loss of sexual desire, anxiety, diarrhea, drowsiness, trouble sleeping, and many more. Extensive side effects include severe allergic reactions, bloody stools, severe and painful erection, unfamiliar agitation, panic attacks, and many others. Paxil also carries out fatal side effects and one of the most common is the Serotonin syndrome, which happens when, drugs such as Paxil is taken together with anti-migraine drugs.

Sertraline hydrochloride, more commonly known as Zoloft, may also treat depression, but may cause side effects which may get pretty adverse. Pfizer is the manufacturer of Zoloft and was approved by the FDA in 1997. While this medicine is popular as an anti-depressant, it is also used by and prescribed for patients with obsessive- compulsive disorder, panic disorder and PMDD or premenstrual dysphoric disorder. More or less Zoloft has the same normal and extensive side effects with Paxil but one thing that should be remembered is that Zoloft cannot or should not be taken by a patient who is under electroconvulsive therapy. Because of the popularity of Zoloft and the adverse side effects associated with it, it was banned in the Great Britain in 2003 from being used by patients under 18 years old. It was because studies have shown that Zoloft induces suicidal thoughts on younger individuals.

If you are allergic to any ingredient of Paxil or Zoloft, then it is best that you do not use them. You can’t also take Paxil or Zoloft if you have taken in other medications such as monoamine oxidase inhibitor (MAOI) and fenfluramine derivative. If you have taken such medications, you must first consult your doctor before taking in any Paxil or Zoloft. When you are having serious side effects from taking these medications, it is best to consult your doctor too.

One last fact about Paxil and Zoloft is that the side effects of both of these drugs gave way to the rise of litigation suits concerning the usage of these two medications.



GlaxoSmithKline is the company which manufactured Paxil while Pfizer is the manufacturer of Zoloft.

Paxil went out in the early 90’s while Zoloft was approved by the FDA in 1997.

Paxil must not be taken in together with other medications while Zoloft should not be taken in if you are undergoing electroconvulsive therapy.

Paxil litigation cases may take a long time to evaluate, while Zoloft was banned for children in Britain.

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  1. is it ok to take zoloft and paxil together….I have been on paxil (aropax) for years but experienced sleep problems….my doctor put me on zoloft, which is much better, but I have no sexual desire at all on zoloft…..So to rectify this I have been taking zoloft 100mg with half my old dose of paxi 30mg…….which seems so far to be working great…..is this safe?

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  3. I’ve been taking paxil 40mg for the last 11yrs and my doctor has been wanting to switch me to Zoloft 100 mg and now is convincing me. But she wants me to switch from one day to another! I’m worried that I might get withdrawal? I’m also taking clonazepam 1mg for the same 11yrs but going to continue those. Any advice that could help me? Ian currently in my first trimester of pregnancy and I have tooken these medications in prior pregnancies with no complications. Thanks in advance.

  4. I have been on paxil for 10 yes. I don’t feel it working anymore. I cry all the time. For no reason. People call me crybaby and I have lost most of my family and life long friends. Does anyone else cry all the time

    • Keep fighting through it, with depression, we’ve all been where you are. Go see your doctor immediately to look at other options available.

    • Hi All, I think Im really late with my post but to be honest none of these pills work I have been prescribed both and finally I realized that it was my current situation affecting me which was mydead end job. So I decided to take care of me and surround myself with people who lift me up and have a positive view in life. I have been a Christian for over 13+ years and trust me we are not exempt from worldly issue such as depression and anxiety, but I was able to put my faith in God and not in me or the pills anymore and I am now awaiting God’s will in my life. I look forward to a brighter future with Christ leading my every step and knowing that if I fall he is holding on.

    • Up your dosage. 10 mg is a very low dosage. I take 40 mg, and i don’t cry anymore. I walked around crying too. I even cried on a interview. Tell your doctor.

  5. I would like to report that while on Paxil for 19 years I developed severe muscular problems. I’ve gotten to the point where I couldn’t walk farther than my bedroom to living room without total muscle fatigue. Even smiling would cause muscular fatigue in my face. Finally after much testing my neurologist told me it was the Paxil doing it. After an accelerated weening process he prescribed Zoloft. I had 2 good weeks where my muscles started to feel better. Then after being on the Zoloft for a couple of weeks the severe muscle fatigue came back with a vengeance. I’m calling him tomorrow to report this and stop the Zoloft. I can’t lie, I’m terrified of the withdrawals, I just hope they aren’t as bad as the Paxil withdrawals.
    If anyone else reading this experienced severe muscle fatigue please let me know, thanks.

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