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Difference Between Melatonin and Melatonin II

Melatonin vs Melatonin II

Melatonin and Melatonin II are synthetic peptides developed at the Arizona University in 1981. They were developed with the end in view of mirroring the function of a natural organism called melanocyte-stimulating hormone. This melanocyte-stimulating hormone, as you must have taught in school, is associated with melanin, a hormone that is responsible for the creation and distribution of pigment in the skin, hair, and eyes.

Melatonin and Melatonin II have revolutionized skin tanning to a certain degree because, unlike other tanning agents, these peptides may not need the help of ultraviolet light to serve their purpose anymore. They appear as white powders made into an injectable solution with the addition of bacteriostatic water. Another similarity between the two is the fact there are no limits as to how long a person can take them.

While already very popular, both are not yet recognized by any state or national drug administration.

Differences in Name

Melatonin is called by different names, among them, Melatonin 1, MT, and Afamelanotide. Melatonin II, on the other hand, is simply called by just one other name, MTII.

Differences in Structure

Melatonin is straight and full-length, while Melatonin II is short and circular.  Melatonin does not bid well to other receptors, but Melatonin II does. Melatonin also has longer amino acid sequences than Melatonin II.

Differences in Functions

Although both of these synthetic peptides are used in artificial skin tanning, Melatonin is specifically involved in the prevention of light-related skin disorders, while Melatonin II is used to treat erectile dysfunction, a sexual disorder wherein a man cannot achieve an erection.

Differences in Effectiveness

Melatonin is less effective so a person needs it in double or more doses than Melatonin II to experience it. Melatonin II is already highly effective even in small doses.

Differences In Side Effects

There are no known or highly publicized Melatonin side effects. If there are, they are fewer than its counterpart. Melatonin II’s side effects include: nausea, flushing of the face, vomiting, and the appearance of moles.

Differences in Manufacturers

Melatonin is developed by an Australian company, Clinuvel, while Melatonin II is developed by an American company, Palatin Jechs.


  1. Melatonin and Melatonin II are two types of peptides used in artificial skin tanning. Both appear as a white powder and are injected into the body as a solution. The solution is made by mixing the powder with some amount of bacteriostatic water.
  2. Melatonin and Melatonin II are synthetic in nature, and they mimic the melanocyte-stimulating hormone. This hormone is associated with melanin, a hormone responsible for the pigmentation in hair, skin, and other areas.  Melatonin and Melatonin II are primarily used for artificial tanning of the skin. They are effective even without the help of ultraviolet rays.
  3. In terms of structure, Melantonin and Melatonin II are very different. Melatonin is straight and full-length whereas Melatonin II is short and circular.
  4. Aside from artificial tanning, Melatonin is used as a preventive measure for light-associated skin diseases while Melatonin II is used for erectile dysfunction, libido enhancement, and spontaneous erection.
  5. Melatonin has no apparent side effects. Meanwhile, Melatonin II has the following effects when the substance is consumed: nausea, vomiting, face flushing, and development of moles.
  6. Both substances can be taken for an unlimited period of time. There is no prescribed time period in using both substances.
  7. Commercial Melatonin is developed and distributed by Clinuvel, an Australian company. The same is done by Palatin Jechs, an American company for Melatonin II.

Many people are using either Melatonin or Melatonin II or both. But remember that these peptides are not yet regulated. It might be wiser, at least for now, to read as much as you can about these peptides and to wait until more studies are conducted to determine its effectiveness and safety.

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  1. “melatonin” is the wrong word. The word is “melanotan”.

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