Difference Between Similar Terms and Objects

Difference between Epidermis and Dermis

The skin is the largest organ in the body, correspondingly, it plays very significant roles when it comes to health and overall well being. The skin serves many purposes. However, most people take the skin for granted and do not appreciate the importance not until they suffer from injury, various diseases and bad conditions. Outmost care of this organ is very essential.

To better take care of the skin, it is salient to understand the different structures and functions of each. Not all people know that the skin is made up of different parts. In fact, the skin is divided into three main layers, namely: the epidermis, dermis and hypodermis.

The epidermis and dermis are commonly confused, but the two are completely different structures of the skin that plays different distinct functions in the body. The following paragraphs are in depth discussions to further understand these two layers of the skin.


This is the outermost layer of the skin.  It is approximately 0.05 – 1.5 mm thick. Several cells make up the epidermis. The keratinocytes are by far the most abundant type of cell in this layer. Then there are the melanocytes, which are produced by the corns of the color, substance melanin that gives tone to the skin. The Langerhan’s cells are also found in this layer, these cells interact with the white blood cells and serves as the immune defense.

Layers of the Epidermis (from deepest to most superficial layer)

  1. Stratum basale (Stratum germinativum)

This is the deepest layer of the skin where mitosis occurs. This is the process where cells divide leading to formation of new epidermal skin cells. After mitotic division, these cells undergo keratinisation – progressive cell maturation, and migrate to the surface of the skin.

  1. Stratum spinosum

The cells that generate from the Stratum basale soon accumulate in this layer through demosomes –structures that join adjacent cells together.

  1. Stratum granulosum

As cells progressively mature and undergo keratinisation they accumulate in this layer and gather dense basophilic keratohyalin granules (these are granules found in the cells of keratinizing epithelia).

  1. Stratum lucidum

This layer varies throughout the body depending on the frictional forces. The thickest Stratum lucidum are found on the palms of the hands and soles of the feet.

  1. Stratum corneum

This is the outermost layer of the epidermis and primarily consists of dying and dead skin cells filled with mature keratin. These cells underwent substance change and break down complex chemicals within the cells that eventually causes their death.



The dermis is the middle layer of the skin. It is about 0.3 – 3.0 mm. This basically consists of connective tissues. The essential components of this layer are firmer protein collagen and the fibers of the elastic protein. In addition, this layer contains all types of immune cells and factors that protect the skin.

Layers of the Dermis

  1. Papillary Dermis

This dermis layer consists of areolar connective tissue, ridges that extend into the epidermis and dermal papillae that increase the surface area of this layer.

Note: The ridges are responsible for the fingerprints on objects when touched.

  1. Reticular Dermis

This layer consists of dense connective tissue that contains interlacing bundles of coarse elastic fibers and collagen. Small quantities of hair follicles, nerves, adipose tissue oil glands and sweat gland ducts reside in between the fibers.

Epidermis vs. Dermis




Blood Vessels

The epidermis does not contain blood vessels. However, they get the oxygen and nourishment that diffuse upward from the deeper layers.

The dermis has a thin network of vessels known as capillaries densely located under the epidermis.


The epidermis does not contain nerves.

The dermis contains nerves that conduct nerve impulses through the central nervous system towards the brain. Sense of pain originates from the open nerve endings of this layer.


  • Responsible for the skin cell renewal and regeneration process.

  • Barrier between the internal structures of the body and the external environment.

  • Prevents microorganisms, water and other substances, from entering the body.

  • Protects from the UV rays of the sun and from other environmental pollutants.

  • Provides the skin with extensibility, strength, firmness and elasticity.

  • Helps diffuse oxygen and nutrients to the outer layer of the skin.

  • Contains antibodies that fight microbes and other hazardous substances.

  • This layer initiates the inflammatory process during skin injury to increase the blood in the blood stream to make the immune cells navigate easier to combat microorganisms.

Note: The epidermis and the dermis are separated by the dermo-epidermal junction. This junction holds the two layers together through the help of fibers, collagen and desmosomes. This is so elastic that it prevents the two layers from separating from leach other due to the high shearing stress.

Sharing is caring!

Search DifferenceBetween.net :

Email This Post Email This Post : If you like this article or our site. Please spread the word. Share it with your friends/family.

Leave a Response

Please note: comment moderation is enabled and may delay your comment. There is no need to resubmit your comment.

Articles on DifferenceBetween.net are general information, and are not intended to substitute for professional advice. The information is "AS IS", "WITH ALL FAULTS". User assumes all risk of use, damage, or injury. You agree that we have no liability for any damages.

See more about : ,
Protected by Copyscape Plagiarism Finder